The current understanding of the clinical efficacy, safety and indications
for the use of sublingual-swallow immunotherapy (SLIT) in the treatment
of allergies is embodied in the studies, papers and publications referenced
in this document. Over 100 citations are contained in this bibliography,
including over 60 peer-reviewed studies published since 1995. Internationally,
SLIT is used widely (50% in some European countries), with full regulatory
and government backing. U.S. Allergy leaders are writing in support
of SLIT. (See section 1) The World Health Organization indicated its
use in its 1998 position paper. In November 2001, an international
workgroup, including U.S. allergists, published the ARIA (Allergy
Rhinitis and its affect on Asthma) guidelines indicating SLIT as well.
Since that time dozens of well-designed studies (randomized, double-blind,
placebo-controlled) have been peer reviewed and published. Cochrane
Review has performed a meta-analysis and determined SLIT both safe
and effective (see section 1). Two additional pivotal studies to note
are the “10 year study…” showing the long lasting effect of SLIT (see
section 1), and the 2004 head-to-head study of SLIT to injection in
a double-blind, double-dummy approach (see section 2). Few studies
(two) could be found showing that SLIT was not effective, and those
results are equivocal and dated. Additional research efforts are underway
in the U.S. and internationally, this document will updated periodically
to include further publications.
The following pages are a comprehensive
bibliography of studies divided into six categories, with citations
presented in chronological order;
1. Recent Major Guidelines and Papers;
includes over 30 significant position papers
2. Studies/Abstracts; includes nearly
50 studies
3. Comparison Studies of Sublingual and
Subcutaneous Antigen Administration; includes 2004 randomized, placebo-controlled,
double-blind, double-dummy study.
4. Safety and Quality-of-Life Related
Studies;
5. Mechanisms of Sublingual Immunotherapy;
current understanding of mucosal immunity.
6. Other Indications for Treatment; other
sensitizations where SLIT has been effective.
The scrutiny of SLIT has been intense,
particularly in the past five years. The volume of research and its
consistency is presented as evidence of the value of SLIT to patients.
We thank you for your interest in this topic and invite you to provide
us feedback and let us know if you would like to receive updates a
new research and publications are added.
Comprehensive list of Studies & Papers
1. Recent Major Texts, Guidelines, Papers and Editorials
1. Nelson, Harold “Advances in upper
airway diseases and allergen immunotherapy”, Journal of Allergy and
Clinical Immunology, Vol. 113, No. 4, Pages 635-42, April 2004
2. Passalacqua, Giovanni, et al “Efficacy
and safety of sublingual immunotherapy”, Annals of Allergy, Asthma,
and Immunology, Vol. 93;1, pgs. 3-12, 2004.
3. Portnoy J. “Allergen Immunotherapy
in the Prevention of Asthma” Current Opinion Allergy Clinical Immunology
4(2): 131-136, 2004.
4. Passalacqua, G, Canonica, GW, “Sublingual
or injection immunotherapy: the final answer?” Allergy 2004: 59: 37-38
5. Mosages, R “The role of hyposensitization:
do we need to start rethinking?”, Clinical Opinion in Allergy and
Clinical Immunology, 2004, Vol. 4, pgs. 155-157
6. Norman, Philip S. “Immunotherapy:
1999-2004”, Journal of Allergy and Clinical Immunology, June 2004
Vol. 113, No. 6, pgs. 1013-1023.
7. Passalacqua G, Lombardi C, Canonica
GW “Sublingual Immunotherapy: An Update”, Current Opinion in Allergy
and Clinical Immunology, Vol. 4 (1), February 2004
8. Markert, UR and Elsner P. Local Immunotherapy
in Allergy, Chemical Immunology and Allergy (lead chapter by D. Morris,
et al) Vol. 82, Karger, Basel, Switzerland 2003.
9. Wilson, DR Torres, LM, and Durham
SR “Sublingual immunotherapy for allergic rhinitis” (Cochrane Review),
The Cochrane Library, Oxford, England, Issue 2. 2003.
10. Canonica, G. Walter and Passalacqua,
G. “Non-injection routes for immunotherapy”, Journal of Allergy and
Clinical Immunology, Vol. 111, No. 3 pgs. 437-448, March 2003
11. Nelson, Harold S. “Advances in upper
airway diseases and allergen immunotherapy”, Journal of Allergy and
Clinical Immunology, Vol. 111, No. 3, pgs. S793-798, March 2003.
12. Di Rienzo, V., Canonica, GW, and
Passalacqua G. “Long-lasting effect of sublingual immunotherapy in
children with asthma due to house dust mite: a 10 year prospective
study”, Clinical and Experimental Allergy, Vol. 33, pgs. 206-210,
2003
13. Bielory L. and Heimall “Review of
complementary and alternative medicine in treatment of ocular allergies”,
Current Opinion in Allergy and Clinical Immunology, Vol. 3, pgs. 395-399,
2003.
14. Passalacqua, G, Baena-Cagnani, Carlos,
Berardi, M, Canonica, G Walter “Oral and sublingual immunotherapy
in pediatric patients”, Current Opinion in Allergy and Clinical Immunology,
Vol. 3(2), pgs. 139-145, April 2003
15. Li, J et al, “Allergen immunotherapy:
a practice parameter”, Journal of Allergy and Clinical Immunology,
Vol. 90, January 2003 (see Summary Statement 57, Page 27)
16. Kagi M.K. and B. Wuthrich, Review
Article, “Different methods of local allergen-specific immunotherapy”,
Allergy, Vol. 57, pgs. 379-388, 2002
17. Reiber, Mark E. “Sublingual Administration
of Allergen Desensitization” Tennessee Medicine, pgs. 465-467, November
2002
18. Douglass, J. and O'Hehir, R. (Editorial)
"Specific allergen immunotherapy: time for alternatives?",
Clinical and Experimental Allergy, Vol. 32, pgs. 1-3, 2002
19. Bousquet, J. The new ARIA guidelines:
putting science into practice, Clin Exp All Rev 2002; 2:38-43
20. Volpe, A. Della, et al “Sublingual
Allergen-Specific Immunotherapy in Allergic Rhinitis and Related Pathologies:
Efficacy in a Paediatric Population” International Journal of Immunopathology
and Pharmacology, Vol 15, No. 1, pgs. 35-40, 2002.
21. Malling, H. “Is Sublingual Immunotherapy
Clinically Effective?” Current Opinion Allergy and Clinical Immunology,
Vol 2, No. 6 pgs. 523-532, 2002.
22. Allergic Rhinitis and its impact
on Asthma (ARIA) Workshop Report. ARIA Workshop Group, Journal of
Allergy and Clinical Immunology, Supplement, 11/2001:Vol. 108, No.
5
23. Bousquet, J., ARIA Workshop Group
Guidelines J All Clin Immunol pgs S242-S245, 2001
24. Passalacqua G. & Canonica, G.W.
"Allergen-Specific Sublingual Immunotherapy for Respiratory Allergy",
BioDrugs, Vol. 15 (8) pgs. 509-519, 2001
25. Morris, D.L. "Current use of
sublingual-swallow immunotherapy", Current Opinion in Otolaryngology
& Head and Neck Surgery, Vol. 9, No. 3, pgs. 179-180, June 2001.
26. Marogna, M. et al “Clinical Practice
Improvement Program for Immunotherapy of Respiratory Allergic Diseases”,
International Journal of Immunopathology and Pharmacology, Vol. 14,
No. 2, pgs 93-101, 2001.
27. Allergen Immunotherapy: Guidelines,
Update and Recommendations of the World Health Organization, Theodoropoulos
& Lockey, Allergy & Asthma Proc. Pg. 159-66, May-June 2000,
Vol. 21, No.3.
28. Frew, Anthony, et al "Sublingual
Immunotherapy", Journal of Allergy Clinical Immunology, pgs.
441-444, March 2001.
29. Brown, J.L. & Frew, A.J. (Editorial)
"The efficacy of oromucosal immunotherapy in respiratory allergy",
Clinical & Experimental Allergy, Vol. 31, Is. 1, pg 8-10, January
2001
30. Editorial, "The efficacy of
oromucosal immunotherapy in respiratory allergy", Clinical and
Experimental Allergy, Vol. 31, pgs. 8-10, 2001.
31. Rakoski, Jurgen and Wessner, Dirk
"A Short Assessment of Sublingual Immunotherapy", International
Archives of Allergy and Immunology, Vol. 126, pgs. 185-187, 2001.
32. Pineda-Algorta, J. et al “Study of
the efficacy of sublingual immunotherapy in patients with grass pollen
sensitization”, (abstract) “Mini Symposium 3 Sublingual Immunotherapy”
Allergy 55 Suppl. Vol. 63: pg. 24, 2000
33. Ano-Garcia, M. et al “Efficacy and
safety of sublingual immunotherapy in patients with sensitization
to Dermtophagoides pteronyssinus” (abstract) “Mini Symposium 3 Sublingual
Immunotherapy” Allergy 55 Suppl. Vol 63: pg. 24, 2000
34. Khinchi, M.S. et al “Clinical efficacy
of sublingual-swallow and subcutaneous immunotherapy in patients with
allergic rhinoconjunctivitis due to birch pollen. A double-blind,
double dummy placebo-controlled study (abstract), “Mini Symposium
3 Sublingual Immunotherapy” Allergy 55 Suppl. Vol 63: pg 24, 2000
35. Donato, R.M. Patients with allergic
rhinitis from Argentine treated with SLIT (sublingual immunotherapy)
a non-injective route - Abstract presented October 2000 IACAI Conf.
36. Malling, Hans-Jergen "Allergen-specific
immunotherapy. Present state and directions for the future",
Allergy, Vol 54, pgs. 30-33, 1999.
37. Passalacqua, G. et al, "Oral
and Sublingual Immunotherapy: General Aspects and Critical Considerations",
WMW Themenheft: Hyposensibilsierung, pgs 433-437, 1999.
38. Donahue, JG et al, “Utilization and
cost of immunotherapy for allergic asthma and rhinitis”, Annals of
Allergy, Asthma and Immunology, Vol. 82, pgs. 339-347, April 1999
39. Bousquet J, Lockey R. Malling HJ,
Allergen immunotherapy: therapeutic vaccines for allergic diseases.
World Health Organization Position Paper Allergy Vol 53 Suppl 44 pgs
1-29, 1998
40. Malling, H.J. Editorial "Sublingual
Immunotherapy", Clinical Experimental Allergy, Vol. 26, pgs.
1228-1231, 1996.
41. Passalacqua G. et and G.W. Canonica
“Alternative routes for allergen-specific immunotherapy” J Invest
Allergol Clin Immunol, Vol. 6(2) pgs. 81-87, March-April 1996.
42. Creticos, P.S. A review of oral specific
immunotherapy, Expressions on allergen specific immunotherapy, Stallergenes
S.A., Vol. 1, June 1995. (US Based DBPC Study)
2) Studies/Abstracts
1. Khinici…Malling, “ Clinical efficacy
of sublingual and subcutaneous birch pollen allergen-specific immunotherapy:
a randomized, placebo-controlled, double-blind, double-dummy study”,
Allergy, 2004: 59: 45-53
2. Tonnel, A.B. et al “Allergic rhinitis
due to house dust mites: evaluation of the efficacy of specific sublingual
immunotherapy”, Allergy, Vol. 59, pgs. 491-197, 2004
3. Bufe, A. et al “Efficacy of sublingual
swallow immunotherapy in children with severe grass pollen allergic
symptoms: a double-blind placebo-controlled study, Allergy, Vol. 59(5),
pgs 498-504, May 2004
4. Pajno, GB, et al “Sublingual immunotherapy
abrogates seasonal bronchial hyperresponsiveness in children with
Parietaria-induced respiratory allergy: a randomized controlled trial
dagger”, Allergy, Vol. 59(8), pgs. 883-887, August 2004
5. Melranci, C. Matteoli M. “Efficacy
of allergoid sublingual immunotherapy in children with asthma and/or
allergic rhinoconjunctivitis: Comparison study with drugs” Journal
of Allergy and Clinical Immunology, February 2004 Supplement, Vol.
113, Number 2. (abs.)
6. Bassi M. et al “High dose sublingual
immunotherapy: Economic evaluation from an Italian observational data
base study” Journal of Allergy and Clinical Immunology, February 2004
Supplement, Vol. 113, Number 2. (abs.)
7. Andre, et al “A Double-Blind Placebo-Controlled
Evaluation of Sublingual Immunotherapy with a Standardized Ragweed
Extract in Patients with Seasonal Rhinitis”, Int Arch Allergy Immunol,
131: pgs. 111-118, 2003.
8. Ippoliti, F, et al “Immunomodulation
during sublingual therapy in allergic children”, Pediatric Allergy
and Immunology, Vol. 14, pgs. 216-221, 2003
9. Pajno, G.B. et al, Abstract “Parietaria
Pollen Sublingual Immunotherapy for Asthmatic Children: Seasonal Behavior
in Methacholine PC20, Journal of Allergy and Clinical Immunology,
February 2003
10. Mortemousque, B, et al “House-dust
mite sublingual –swallow immunotherapy in perennial conjunctivitis:
a double-blind, placebo-controlled study”, Clinical and Experimental
Allergy, Vol. 33, pgs. 464-469, 2003.
11. Gonzalez, E. et al, Abstract “Efficacy
and Safety of a Standardized Sublingual Therapeutic Vaccine of Cat
Epithelia Extract, Journal of Allergy and Clinical Immunology, page
S200, February 2003
12. Cirla, A.M. et al “A pre-seasonal
birch/hazel sublingual immunotherapy can improve the outcome of grass
pollen injective treatment in bisensitized individuals. A case-referent,
two year controlled study”, Allergol et Immunopath Vol. 31(1) 31-43,
2003.
13. Torres Lima, M. et al, Grass pollen
sublingual immunotherapy for seasonal rhinoconjunctivitis: a randomized
controlled trial, Clin Exp Allergy 2002; 32-507-14
14. Silvestri, M et al. “Changes in Inflammatory
and Clinical Parameters and in Bronchial Hyperreactivity in Asthmatic
Children Sensitized to House Dust Mites Following Sublingual Immunotherapy”,
J Invest Allergol Clin Immunol (abstract) Vol 12: No. 1 pgs 6-7, 2002
15. Velarde-Domiquez, T. et al, Abstract
“Clinical effectiveness and security of sublingual immunotherapy as
a treatment for allergy asthma secondary to Dermaphgoides in pediatric
population”, Rev Sanid, Milit Mex Vol. 56, No. 1, pgs 10-14, 2002.
16. Molina, A. Criado et al “Inmunoterapia
con un extracto oral de Alternaria en el asma infanil. Eficacia clinica,
seguridad, repercusiones sobre parametros in vivo e in vitro Allergol
et Immunpathol, Vol. 30(6) 319-30, 2002.
17. Olaguibel, J.M., et al “Adherence
to and Safety of a High Dose Sublingual Immunotherapy Regimen With
a Standardized Grass Pollen Extract”, Journal Allergy Clinical Immunology,
Vol. 109, No. 1, pg. S201, January 2002.
18. Pajno, G.B. et al, “Impact of Sublingual
Immunotherapy on Seasonal Asthma of Allergic Children to Parietaria
Pollen Treated with Inhaled Fluticasone Propionate, Journal Allergy
Clinical Immunology, Vol. 109, No. 1, pg. S200, January 2002.
19. Ariano, R. et al “Efficacy of sublingual
specific immunotherapy in Cupressaceae allergy using an extract of
Cupressus arizonica. A double blind study, Allergol Immunopathol,
Vol. 29, No. 6, pgs. 238-244, 2001.
20. Bahceciler, et al. "Efficacy
of sublingual immunotherapy in children with asthma and rhinitis:
a double-blind, placebo-controlled study." Pediatric Pulmonology,
32:49-55 2001
21. Caffarelli, C, et al. "Preseasonal
local allergoid immunotherapy to grass pollen in children", Allergy,
2000, 55, 1142-1147
22. Course of Birch, Bat V1 and Bat V2,
IgE levels following Sublingual-Swallow and Parenteral Birch Immunotherapy.
Kinchi, Poulsen, Malling-Denmark. Dieierlaurent, Berjout, Andre-France
July 2000
23. Valle, C. et al "Effects of
sublingual immunotherapy in patients sensitised to Ambrosia. An open
controlled study" Allergol et Immunopathol, Vol. 28 (6) pgs 311-317,
2000
24. Mastrandrea, F. et al "Specific
sublingual immunotherapy in atopic dermatitis. Results of a 6-year
follow-up of 35 consecutive patients", Allergol et Immunopathol,
Vol. 28 (2) pgs. 54-62, 2000.
25. Pajno, GB, et al "Clinical and
Immunological Effects of Longterm Sublingual Immunotherapy in Asthmatic
Children Sensitized to Mites: A Double-blind Placebo Controlled Study,
Allergy, Vol. 55, pgs 842-849, 2000.
26. Guez, S. et al "House dust mite
SLIT in perennial rhinitis: A double blind placebo controlled study,
Allergy, Vol. 55, pgs. 369-75, 2000.
27. Pradalier, A. et al "Sublingual-swallow
immunotherapy (SLIT) with a standardized five-grass-pollen extract
(drops and sublingual tablets) versus placebo in seasonal rhinitis",
Allergy, Vol. 54, pgs. 819-828, February 1999.
28. Bousquet, J. et al "Sublingual-swallow
immunotherapy (SLIT) in patients with asthma due to house-dust mites:
a double blind, placebo-controlled study", Allergy, Vol. 54 (3)
pgs. 249-260, March 1999.
29. Purello, D'Ambrosio, et al "Sublingual
immunotherapy: a double blind placebo controlled trial with Parietaria
judaica extract standardized in mass units in patients with rhinoconjunctivitis,
asthma or both", Allergy, Vol. 54: 968-973, 1999.
30. La Rosa, Mario, et al "Double-blind
placebo-controlled evaluation of sublingual-swallow immunotherapy
with standardized Parietaria judaica extract in children with allergic
rhinoconjunctivitis", Journal AllergyClinical Immunology, pgs.
425-432, August 1999.
31. Passalacqua, Giovanni, et al "Clinical
and immunologic effects of a rush sublingual immunotherapy to Parietaria
species: A double-blind, placebo-controlled trial", J Allergy
Clin Immunol, pgs 964-968, November 1999.
32. Di Rienzo, V, et al "Grass pollen
specific sublingual/swallow immunotherapy in children: open-controlled
comparison among different treatment protocols", Allergol et
Immunopathol, Vol. 27 (3) pgs 145-151, 1999.
33. Vourdas, D. et al "Double-blind,
placebo-controlled evaluation of sublingual immunotherapy with standardized
olive pollen extract in pediatric patients with allergic rhinoconjunctivitis
and mild asthma due to olive pollen sensitization", Allergy,
Vol 53, pgs 662-672, 1998
34. Clavel, R., Bousquet, J., et al "Clinical
efficacy of sublingual-swallow immunotherapy: a double-blind, placebo-controlled
trial of standardized five-grass-pollen extract in rhinitis",
Allergy, Vol. 53, pgs 493-498, May 1998.
35. Horak, F. et al "Immunotherapy
with sublingual birch pollen extract. A short-term double blind placebo
study", Invest Allergol Clin Immunol, Vol 8, No. 3, pgs. 165-171,
May-June 1998.
36. Hordijk, G.J., et al "Sublingual
immunotherapy with a standardised grass pollen extract; a double-blind
placebo-controlled study", Allergol, et Immunopathol., Vol. 26,
No. 5, pages 234-240.
37. Passalacqua, Giovanni, et al "Randomised
controlled trial of local allergoid immunotherapy on allergic inflammation
in mite-induced rhinoconjunctivitis", The Lancet, Vol. 351, pgs
629-632, February 28, 1998.
38. Luwema, R.A., et al "Sublingual
Immunotherapy with a Standardized Grass Pollen Extract (Oralgen);
a placebo controlled study", The Journal of Allergy and Clinical
Immunology, Vol. 99, No. 1, Part 2, Abstract #282, January 1997.
39. Passalacqua, G., et al "Clinical
and Immunological Effects of a Long-term Sublingual-oral Immunotherapy
to Mite: A Double Blind Study", The Journal of Allergy and Clinical
Immunology, Vol. 99, No. 1, Part 2, Abstract # 1630, January 1997.
40. Van Deusen, Matthew, et al “Efficacy
and safety of oral immunotherapy with short ragweed” Annals of Allergy,
Asthma & Immunology, Vol. 78, pgs 573-580, June 1997.
41. Gozalo, F. et al "Clinical efficacy
and tolerance of two year Lolium perenne sublingual immunotherapy",
Allergol. Et Immunopathol., Vol 25 (5), pgs. 219-227, 1997.
42. Passalacqua, G. "Sublingual
immunotherapy: Accumulated experience", J Invest Allergol Clin
Immunol, Vol. 7(5), pgs. 364-366, September/October 1997.
43. Hirsh, T. et al. Double blind placebo
controlled study of sublingual immunotherapy with house dust mites
extracts in children. Pediatric Allergy & Immunology, 1997: 8:
21-27.
44. D'Ambrosio, F. Purello, et al, "Rush
sublingual immunotherapy in parietaria allergic patients", Allergol.
Et Immunopathol, Vol: 21: No 4, pgs 146-151, 1996.
45. Troise, C. et al. "Sublingual
immunotherapy in Parietaria pollen-induced rhinitis: A double-blind
study", Journal of Investigational Allergology and Clinical Immunology,
Vol. 5(1), pgs. 25-30, 1995.
46. Clavel, R. et al. "Reduction
of Corticosteroid Therapy by Sublingual Immunotherapy. Double Blind
Study Against Placebo of Standardised 5 Grass Pollen Extract in Rhinitis",
Allergy, Vol. 50(26), pg. 279, 1995.
47. Giovane, A.L., et al. "A three-year
double-blind placebo-controlled study with specific oral immunotherapy
to Dermatophagoides: evidence of safety and efficacy in paediatric
patients", Clinical and Experimental Allergy, Vol. 24, pgs. 53-59,
1994.
48. Sabbah, A. et al. "A double-blind,
placebo-controlled trial by the sublingual route of immunotherapy
with a standardized grass pollen", Allergy, Vol. 49, pgs. 309-13,
1994.
49. Casanovas, M. et. al. "Double-blind,
placebo-controlled clinical trial of preseasonal treatment with allergenic
extracts of Olea europaea pollen administered sublingually",
Journal of Investigational Allergology and Clinical Immunology Vol.
4(6), pgs. 305-314, November-December 1994.
50. Tari, M.G., et al. "Immunologic
evaluation of 24 month course of sublingual immunotherapy." Allergol.Et
Immunopathol., Vol. 22, No. 5, pgs. 209-216, 1994.
51. Tari, M.G., et al. "Efficacy
of sublingual immunotherapy in patients with rhinitis and asthma due
to house dust mite-A double blind study.", Allergol. Et Immunopathol.,
Vol. 18, No. 5, pgs. 277-284, 1990.
52. Leng, Xiao, et al. "A double-blind
trial of oral immunotherapy for Artemisia pollen asthma with evaluation
of bronchial response to the pollen allergen and serum-specific IgE
antibody", Annals of Allergy, Vol. 64, pgs. 27-31, Jan. 1990.
53. Taudorf, Ebbe, et. al. "Oral
immunotherapy in birch pollen hayfever", J Allergy Clinical Immunology,
Vol. 80, No. 2, pgs. 153-161, Aug. 1987.
54. Van Nierkerk, C.H. and J.I De Wet.
"Efficacy of grass-maize pollen oral immunotherapy in patients
with seasonal hay-fever; a double blind study", Clinical Allergy,
Vol. 17, pgs. 507-513, 1987.
55. Scadding, Glenis K. and J. Brostoff.
"Low dose sublingual therapy in patients with allergic rhinitis
due to house dust mite", Clinical Allergy, Vol. 16, pgs. 483-491,
1986.
3) Comparison Studies of Sublingual and
Subcutaneous Antigen Administrtion
1. Khinici…Malling, “ Clinical efficacy
of sublingual and subcutaneous birch pollen allergen-specific immunotherapy:
a randomized, placebo-controlled, double-blind, double-dummy study”,
Allergy, 2004: 59: 45-53
2. Mungan, Dilsad, et al "Comparison
of the efficacy of subcutaneous and sublingual immunotherapy in mite-sensitive
patients with rhinitis and asthma - a placebo controlled study",
Annals of Allergy, Asthma, and Immunology, Vol. 82, pgs. 485-490,
May 1999.
3. Quirino, T. et al "Sublingual
versus injective immunotherapy in grass pollen allergic patients:
a double blind (double dummy) study, Clinical and Experimental Allergy,
Vol. 26, pgs. 1253-1261, 1996.
4. Bernardis, P., et al. "Injective
versus sublingual immunotherapy in Alternaria tenuis allergic patients,
Journal of Investigational Allergology and Clinical Immunology, Vol
6(1), pgs. 55-62, January-February 1996.
4) Mechanisms of Sublingual Immunotherapy
1. Arikan, C et al. “BCG-induced IL-12
did not improve parameters in asthmatic children treated w/sublingual
immunotherapy”, Clinical and Exp. Allergy, 34-398-405, 2004
2. Reich, M et al. “Nonspecific Plasma
Proteins during Sublingual Immunotherapy”, Local Immunotherapy in
Allergy, Chem Immunol. Basel, Karger, Vol. 82, pgs. 99-108, 2003
3. Bagnasco, et al "Pharmacokinetics
of an allergen and a monomeric allergoid for oromucosal immunotherapy
in allergic volunteers", Clinical and Experimental Allergy, Vol
31, pgs. 54-60, 2001.
4. Marcucci, F. et al "Sublingual
tryptase and ECP in children treated with grass pollen sublingual
immunotherapy (SLIT): safety and immunologic implications", Allergy,
Vol. 56, pgs. 1091-1095, 2001
5. Preliminary analysis of clinical parameters,
plasma proteins and T cell functions of allergic patients after up
to 3 years sublingual immunotherapy- Abstract presented October 2000
0 IACAI conference, U.R. Markert, MD
6. Fanta, C. et al "Systemic Immunological
Changes Induced by Administration of Grass Pollen Allergens via the
Oral Mucosa during Sublingual Immunotherapy", Int Arch Allergy
Immunol, 120: pgs. 218-224, February 5, 1999.
7. Yuksel, H. et al "Sublingual
immunotherapy and influence on urinary leukotrienes in seasonal pediatric
allergy", Invest Allergol Clin Immunol, Vol. 9(5), pgs 305-313,
September/October 1999.
8. Bagnasco, M et al "Absorption
and distribution kinetics of the major Parietaria allergen administered
by noninjectable routes to healthy human beings, Journal Allergy Clinical
Immunology, Vol. 100: pgs. 13-18, 1997.
9. Giannarini, L. "Decrease of allergen-specific
T cell response induced by local nasal immunotherapy", Clin Exp
Allergy, Vol. 28, pgs, 547-551, 1998.
5) Safety and Quality-of-Life Related Studies
1. Scolozzi, RM “Tolerability of the
allergoid sublingual immunotherapy with a monomeric allergoid in patients
with allergic rhinitis and/or asthma” Journal of Allergy and Clinical
Immunology, February 2004 Supplement, Vol. 113, No. 2. (abstract)
2. Silvestris, A. “Tolerability of sublingual
immunotherapy with monomeric allergoid in allergic sensitizations
to house dust mite, Parietaria and grass, Journal of Allergy and Clinical
Immunology, February 2004 Supplement, Vol. 113, No. 2 (abstract)
3. Grosclaude, M, et al “Safety of Various
Dosage Regimens during Induction of Sublingual Immunotherapy”, International
Archives Allergy and Applied Immunology, Vol. 129 (3), pgs 248-253,
March 2003
4. Hasan, H., et al “Short Report – Evaluation
of Immunotherapy for Seasonal and Perennial Allergic Rhinitis Using
Quality of Life Questionnaires”, Current Allergy & Clinical Immunology,
Vol. 16, No. 1, March 2003
5. Lombardi, C. et al "Safety of
sublingual immunotherapy with monomeric allergoid in adults: multicenter
post-marketing surveillance study", Allergy: 56: 989-992, 2001.
6. Lombardi C, et al "Sublingual
immunotherapy is clinically safe in patients with oral allergy syndrome",
Allergy 2000 in press.
7. Andre, C. et al “Safety of sublingual
immunotherapy in children and adults, “Int Arch Allergy Immunol Vol.
121, pgs. 229-234, 2000
8. Madonini, E. et al “Safety and Efficacy
Evaluation of Sublingual Allergen-Specific Immunotherapy – A Retrospective,
Multicenter Study, International Journal of Immunopathology and Pharmacology,
Vol. 13, No. 2, pgs. 77-81, 2000.
9. Di Rienzo, V. et al "Post-marketing
surveillance study on the safety of sublingual immunotherapy in children,"
Allergy, Vol. 54, pgs. 1110-1113, 1999.
10. Ariano, R., et al "Efficacy
and safety of oral immunotherapy in respiratory allergy to Parietaria
judaica pollen. A double-blind study." Invest Allergol Clin Immunol,
Vol. 8, No. 3, pgs. 155-160, May-June 1998.
11. Feliziani, V. et. al. "Safety
and efficacy of sublingual rush immunotherapy with grass allergen
extracts. A double blind study." Allergol. Et. Immunopathol.,
Vol. 23, No. 5, pgs. 224-230, 1995.
6) Other Indications for Treatment (Foods and Chemicals)
1. Severe anaphylaxis to kiwi fruit:
Immunologic changes related to successful sublingual allergen immunotherapy,
Letter to the editor, JACI, June 2003, page 1406-09
2. Patriarca, G. et al. “Oral desensitizing
treatment in food allergy: clinical and immunologic results”, Ailment
Pharmacol Ther, Vol 17, pgs. 459-465, 2003
3. Patriarca, G. “Sublingual Desensitization:
A New Approach to Latex Allergy Problem” Anesth Analg, Vol. 95, pgs.
956-960, 2002.
4. Nucera, E. “Immunological Aspects
of Oral Desensitization in Food Allergy”, Digestive Diseases and Sciences,
Vol. 45, No. 3, pgs. 637-641, March 2000.
5. Patriarca, G., et al "Food allergy
in children: results of a standardized protocol for oral desensitization",
Hepatogastroenterology, Vol. 45 (19): pgs. 52-58, January-February
1998.
6. Morris, D.L. "Intradermal Testing
and Sublingual Desensitization for Nickel", Cutis, Vol. 61, No.
3, pgs. 129-132. March 1998.
7. Panzani, R.C., et al. "Oral hyposensitization
to nickel allergy: preliminary clinical results", Int Arch Allergy
Immunol, Vol. 107 (1-3): pgs. 251-254, May-June 1995.
972-394-4405 (fax)
